Comments from Website author: In many of the cases reported, the argyria onset was after the patient ceased taking the silver solution.
Comments from Physicians at this article's end: None


Argyriasis. Report of a case (author's transl)

Med Clin (Barc), 73: 9, 1979 Nov 25, 386-8
A case of argyriasis in a 45-year-old woman is reported. When the patient was 34 she took for a period of 25 months a silver-containing pharmacological product (colloidal silicon with 0.5 percent of silver) in order to treat an intestinal dyspepsia with diarrheic episodes. A few months after discontinuing the treatment a cutaneous pigmentation of a greyish-blue color extending over the whole body, developed. There was also discoloration of the nails, hair, and of the oral and gingival mucosae. The differential diagnosis with other conditions that also develop anomalies of cutaneous pigmentation was established. It is thought that the appearance of the silver poisoning is due to different factors such as the quantity of silver intake, the individual sensitivity to the metal, and the greater or lesser period of exposure to sunlight. The importance of the skin biopsy in order to confirm the diagnosis is commented on. Typical pathologic findings include the presence of silver granules in the basal membrane of sudoriparous glands, around the pilosebaceous follicles, and in the connective tissue. Lastly, the authors insist on the necessity to avoid the prescription of silver-salt containing drugs as far as possible, since the cutaneous pigmentation is irreversible.

Pardo-Peret P; Sans-Sabrafen J; Boleda Relats M

Language of Publication
Original Title
Argirosis. Descripción de un caso.
Unique Identifier

MeSH Heading (Major)
MeSH Heading
Case Report, Dyspepsia [DT], English Abstract, Female, Human, Middle Age, Mouth, Diseases [CI], Mouth Mucosa [DE], Pigmentation Disorders [CI/PA], Silicones [AE], Silver [TU]

Publication Type
Country of Publication
CAS Registry/EC Number
7440-22-4 (Silver)