Comments from Website author: Nonscientific comments -- There is a relationship between orally taking a type II collagen (Calorad, as an example) and the reduction of arthritis. More scientific -- The authors state that rheumatoid arthritis has, as a potential cause, an autoantigen reaction to "type II collagen". They continue on to state that by orally taking "type II collagen" (the prime ingredient in the product Calorad) there is an desensitization that takes place with a resultant decrease in the swollen and tender arthritic joints. In fact, four subjects in the study had a complete remission of the disease. (Quite a significant finding for those who suffer from arthritis.)
Comments from Physicians at this article's end: None


Effects of oral administration of type II collagen on rheumatoid arthritis

Science 261: 1727-1730 (1993)



Rheumatoid arthritis is an inflammatory synovial disease thought to involve T cells reacting to an antigen within the joint. Type II collagen is the major protein in articular cartilage and is a potential autoantigen in this disease. Oral tolerization to autoantigens suppresses animal models of T cell-mediated autoimmune disease, including two models of rheumatoid arthritis. In this randomized, double-blind trial involving 60 patients with severe, active rheumatoid arthritis, a decrease in the number of swollen joints and tender joints occurred in subjects fed chicken type II collagen for 3 months but not in those that received a placebo. Four patients in the collagen group had complete remission of the disease. No side effects were evident. These data demonstrate clinical efficacy of an oral tolerization approach for rheumatoid arthritis.

Trentham DE, Dynesius-Trentham RA, Orav EJ, Combitchi D, Lorenzo C, Sewell KL, Hafler DA, Weiner HL

Department of Medicine, Beth Israel Hospital, Boston, MA.


MeSH Terms:

Administration, Oral; Adult; Aged; Arthritis, Rheumatoid/immunology; Arthritis, Rheumatoid/drug therapy*; Autoimmune Diseases/immunology, Autoimmune Diseases/drug therapy*, Collagen/therapeutic use, Collagen/adverse effects, Collagen/administration & dosage*, Double-Blind Method, Female, Human, Immune Tolerance, Male, Middle Age, Placebo Effect; Support, Non-U.S. Gov't; Support, U.S. Gov't, P.H.S.; T-Lymphocytes/immunology,



PMID: 8378772, MUID: 93391970